Moreover, in carcinoma-associated fibroblasts (CAFs), ITGA11 signaling pathway may play an important role in carcinoma-associated fibroblasts (CAFs), which means Integrin α11β1 can promote tumor growth and metastatic potential of NSCLC cells by regulating cancer stromal stiffness (Navab et al., 2016). Here, ITGA11 is linked to non-small cell lung carcinoma.