Moreover, in carcinoma-associated fibroblasts (CAFs), ITGA11 signaling pathway may play an important role in carcinoma-associated fibroblasts (CAFs), which means Integrin α11β1 can promote tumor growth and metastatic potential of NSCLC cells by regulating cancer stromal stiffness (Navab et al., 2016). This evidence concerns the gene ITGA11 and carcinoma.