Although it requires validation in future studies, this finding, together with the mTOR inhibitors’ modulating effects on epileptogenesis and tumor growth in TS (Franz & Krueger, 2018), suggests that mTOR genes are implicated in epileptogenesis or brain malformations (or both) as a key modulator of epistasis (gene-to-gene interaction). The gene discussed is MTOR; the disease is cerebral malformation.