MAPT and neurodegenerative disease: Phosphorylation of tau at multiple residues is characteristic of many neurodegenerative diseases, which reduces the affinity of tau to MTs, increases tau self-assembly,[85,86] and finally causes the formation of NFTs.[87,88] The presence of NFTs in specific regions of the brain disrupts synaptic and neuronal communications, leads to progression of memory loss, and produces a rapid impairment of long-term potentiation with induction of toxic functions in the neurons.[43,89]