This overexpression in the neurons can lead to dramatic cell-nonautonomous changes in cerebral endothelial cells, alter the integrity of the cerebral microvasculature, and induce neurodegeneration related to vascular abnormalities.[109] A similar situation occurs in AMD, where dramatic neovascular changes accompany neurodegeneration.[110] Additionally, tau overexpression would result in impaired axonal transport, leading to neurodegeneration. This evidence concerns the gene MAPT and age-related macular degeneration.