MAPT and amyotrophic lateral sclerosis: In addition to AD,[7] tau aggregates were detected in a wide range of neurodegenerative diseases including progressive supranuclear palsy (PSP), corticobasal dementia, argyrophilic grain disease, Pick disease, Huntington disease, FTDP-17, ALS, and Parkinson's disease with dementia.[97,98] Unlike AD that has Aβ depositions in addition to tauopathy, PSP is a relatively pure tauopathy in which only tau deposits are seen.