MAPT and Alzheimer disease: GSK3β is one of the kinases having an important role in NFT formation and dystrophic neurites by tau phosphorylation in the brain.[64,65,66,67] High activity of GSK3β can be detected in the frontal cortex[68] and hippocampus of AD patients.[65] It is notable that Lithium, as a potent GSK3β inhibitor, is being widely prescribed for neurodegenerative disorders such as AD.