Coincidently, by bioinformatic analysis, we found that both hsa_circ_0037251 and the 3′-untranslated region (UTR) of mTOR share miRNA response elements (MREs) of miR-1229-3p, which suggested an association between hsa_circ_0037251 and mTOR in glioma. Here, MTOR is linked to central nervous system cancer.