For example, we have observed that slow IPF fibroblasts are less responsive to IL-4/IL-13 compared with rapid IPF fibroblasts14,23 and these findings were confirmed in the present study with the observation that the immunotoxin IL13-PE had no anti-fibrotic effects in the humanized SCID model of IPF induced by the introduction of stable IPF fibroblasts. This evidence concerns the gene IL4 and idiopathic pulmonary fibrosis.