Up to now, plentiful research has demonstrated the key role of TFH and TFR cells in autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and idiopathic thrombocytopenic purpura (ITP)46,47. The gene discussed is TFRC; the disease is autoimmune thrombocytopenic purpura.