PDAC patients with negative IHC brush border staining of SLC22A3 had significantly shorter PFS (P = 0.041, Log Rank and P = 0.024, Breslow; Fig. 2A) and OS (P = 0.007, Log Rank and P = 0.020, Breslow; Fig. 2B) than patients with positive staining in tumor cells. The gene discussed is SLC22A3; the disease is neoplasm.