The relative expression of 24 of the 41 genes (P38, RAC1, ASK1, MAPKAPK2, TRAF2, PPP5C, MAX, MEF2C, PRAK, bax, Apaf1, caspas3, caspas9, caspas10, caspas6, P53, MYD88, NF-κB, PI3K, EIF4B, EIF4E, FAK, IKK, AKT) was lower after hypoxia plus bacterial infection (HS) than with bacterial infection alone (NC) at the early stage (4 h). This evidence concerns the gene APAF1 and bacterial infectious disease.