RYR1 and myopathy: Taken together, the Ryr1I4895T/+, Ryr1Y522S/+, Ryr1R163C, Ryr1Q1970fsX16/A4329D and Ryr1TM/Inde mice show striking phenotypic similarities to the histopathology, Ca2+ transients, ECC and muscle weakness of RYR1-related core myopathy patients (Jungbluth, 2007).