In addition to the APOE gene (encoding apolipoprotein E) as a major AD risk factor, recent GWASs of AD in Caucasian populations also identified several new genetic loci, including: bridging integrator 1 (BIN1), complement receptor 1 (CR1), clusterin (CLU), phosphatidylinositol binding clathrin assembly protein (PICALM), membrane-spanning 4-domains, subfamily A, member 4 (MS4A4)/membrane-spanning 4-domains, subfamily A, member 6E (MS4A6E), CD2-associated protein (CD2AP), CD33 molecule (CD33), EPH receptor A1 (EPHA1) and ATP-binding cassette transporter A7 (ABCA7) [4–7]. The gene discussed is PICALM; the disease is Alzheimer disease.