At 4 h post infection (p.i.), a 20-fold increase of IL-8 could be measured in supernatants of WT-infected HUVECs compared to the uninfected control (20.3 ± 1.4 x-fold), whereas secretion of IL-8 was significantly lower when HUVECs where infected with Δata (4.5 ± 2.1 x-fold) (Figure 3(a)). The gene discussed is CXCL8; the disease is infection.