Multiple genome-wide association studies have identified non-coding single-nucleotide polymorphisms (SNP) in cis or within the TRPM8 gene (rs10166942[C] is located 950 bp 5′ to the start codon and rs17862920[T] is located within the first intron) are associated with reduced migraine risk (odds ratios of 0.78 and 0.77, respectively)11–13. Here, TRPM8 is linked to migraine disorder.