In this study, we analyzed a large cohort of specimens of soft tissue and bone tumors and sarcoma cell lines to delineate the prevalence of YAP1/TAZ expression in order to identify subgroups of tumors which might be particularly dependent on Hippo-YAP1/TAZ signals and therefore might profit from therapeutic YAP1/TAZ inhibition. Here, YAP1 is linked to bone neoplasm.