When mice were fed with a HFD (60% kcal from fat), the Wdr76−/− mice improved the risk factors of metabolic disorders induced by HFD, such as obesity, insulin resistance, size increments of the epididymal and perirenal fat tissues, hepatic steatosis as well as the increment of expressions of the lipogenic and gluconeogenic genes. This evidence concerns the gene WDR76 and obesity due to melanocortin 4 receptor deficiency.