From various studies performed in CE patients and in experimental models, it is commonly accepted that CE cyst formation is mainly mediated by impairment of dendritic cells (DC) differentiation and maturation, and by the differentiation of specialized regulatory T cells and related cytokines such as Interleukin-10 (IL-10) and transforming growth factor beta (TGF-β)7. The gene discussed is IL10; the disease is cyst.