Firstly, biliary inflammation and injury in PBC are regulated by interleukin 12 (IL-12), interleukin 23 (IL-23) and interferon gamma (IFN-γ)32, so inflammatory cytokines might suppress the maturation of erythrocytes so that the newer and larger reticulocytes accelerate the entry into the peripheral blood circulation. Here, IFNG is linked to primary biliary cholangitis.