IL5 and obesity due to melanocortin 4 receptor deficiency: On the contrary, C57BL/6J displayed higher levels of most of the tested circulating cytokines including IFN-γ, KC/GRO, IL-5, IL-10 and IL-6, which may explain the rapid increased leptin levels at 3d and concur for the higher susceptibility to obesity and insulin resistance in this strain31.