Given previous studies have shown that bleomycin-induced lung fibrosis can be attenuated in mice following over-expression of active Cav-1 by adenovirus or Cav-1 scaffolding domain peptide26,27, we determined whether electroporation-mediated gene transfer of Cav-1 provided efficient protection against bleomycin-induced pulmonary fibrosis without side effect. Here, CAV1 is linked to pulmonary fibrosis.