ITCH and cytomegalovirus infection: In addition to ITCH, UL42 interacted with Neural Precursor Cell Expressed, Developmentally Down-Regulated 4 (NEDD4)- family E3 ligases NEDD4 and NEDD4-like (NEDD4L), which were degraded during early HCMV infection (Figure 5A–B) (Nightingale et al., 2018).