Many studies revealed that genetic variants in CYP24A1 gene have previously been investigated in relation to risk of human diseases, such as coronary artery disease (Shen et al., 2010), hypertension (Varakantham et al., 2019), and obesity with ischemic stroke (Turkanoglu Ozcelik et al., 2018) It can be seen CYP24A1 polymorphisms association with ischemic stroke susceptibility. The gene discussed is CYP24A1; the disease is hypertensive disorder.