In age >64 years, the rs1570669 in CYP24A1 could decrease the risk of ischemic stroke (AG genotype, OR = 0.63, 95% CI = 0.40–0.99, p = .044), and also reduced the ischemic stroke risk (AG–AA genotype, OR = 0.66, 95% CI = 0.43–0.99, p = .044). This evidence concerns the gene CYP24A1 and ischemic stroke.