CDKN1B and metastatic neoplasm: However, the high cytoplasmic p27 scoring group was significantly associated with the presence of metastatic disease during 3‐year (P = 0.018) or 5‐year follow‐up (P = 0.014) (Fig. 1A), demonstrating for the first time a direct association between p27 mislocalization and the development of metastasis in OS patients.