The AGTR2 rs1914711 variant (OR = 6.824; p = 1.448 × 10 -9) located on chromosome X was associated with the risk of T2D by the allele test, and the ARL15 rs4311394 variant (OR = 0.318; p = 0.001) was associated with protection against T2D by the genotype and the Armitage trend test. The gene discussed is ARL15; the disease is type 2 diabetes mellitus.