Our study, therefore, was developed a murine model which mimics various characteristics of human ARDS [12] and in primary culture of microvascular lung endothelial cells from DBA/2 mice (PMLEC) not only to clarify the adhesion of infected erythrocytes to murine lung microvascular endothelial cells but also to understand the relevant aspects of EPCR modulation by the immune response, which can bring important contributions to understanding malaria-associated ARDS. The gene discussed is PROCR; the disease is malaria.