In the P. chabaudi model, infected mice in the absence of ICAM-1 showed less anemia and weight loss, reduced parasite accumulation in both the spleen and liver, and higher peripheral blood parasitemia during acute stage malaria, which presented the possible role of ICAM-1 in the adhesion and pathogenesis of P. chabaudi [18]. The gene discussed is ICAM1; the disease is anemia.