Although the etiology of SLE is still not completely understood, multiple factors including genetics (e.g., IRF5, TLR-7, MECP2, STAT4, and TNFSF4 genes), environmental, gender, and immunological factors such as cytokines and autoantibodies may play a role [1, 2]. The gene discussed is TNFSF4; the disease is systemic lupus erythematosus.