SLE patients, in the present study, demonstrated a significant increase in the expression of SLE susceptibility genes IRF5, TLR7, MECP2, STAT4, and TNFSF4 when compared to healthy volunteers, with MECP2 (α) expression having the highest value followed by IRF5 and MECP2 (β). Here, IRF5 is linked to systemic lupus erythematosus.