SLE patients, in the present study, demonstrated a significant increase in the expression of SLE susceptibility genes IRF5, TLR7, MECP2, STAT4, and TNFSF4 when compared to healthy volunteers, with MECP2 (α) expression having the highest value followed by IRF5 and MECP2 (β). This evidence concerns the gene TNFSF4 and systemic lupus erythematosus.