TNF and cancer: And cancer cell growth also could be inhibited by kaempferol via inhibition of certain P450 isozyme [29], regulation of MAPK pathway [7, 30], inhibition of PLK1 [31], decreasing levels of IL-6 and TNF (tumor necrosis factor) [32, 33], and inhibition of VEGF (vascular endothelial growth factor) via the ERK-NFkB-cMyc-p21 pathway [34].