For instance, engineered melanoma tumor cell‐derived exosomes containing endogenous tumor antigens (gp100 and TRP2) and immunostimulatory CpG DNA could induce potent anti‐tumor effects.180 Similarly, engineered myeloma cell‐derived exosomes expressing endogenous P1A tumor antigen and HSP70 are capable of stimulating dendritic cell maturation and T‐cell immune responses181 (Figure 6a). The gene discussed is PMEL; the disease is neoplasm.