LATS1 and neoplasm: The nucleic‐acid‐rich extracellular vesicles (50–200 nm in diameter) secreted from LATS1/2 deficient tumor cells stimulate the host TLR‐MYD88/TRIF nucleic‐acid‐sensing pathways and promote the production of type I interferon, thus inducing adaptive immune responses.131 Further investigations are essential to explore the signaling mechanisms involved in unidentified proteins or nucleic acids in extracellular vesicles (Figure 3b).