Suppression of Exosomal PD‐L1 by depletion of Rab27A and nSMase2, two important exosomal biogenesis genes, induces systemic anti‐tumor immunity and memory.76 It is worth noting that in addition to PD‐L1, tumor exosomes should contain other proteins or RNAs that also exert immunosuppressive functions, awaiting further investigations. The gene discussed is SMPD3; the disease is neoplasm.