Moreover, by delivering different signals, TEXs can broadly affect the proliferation, apoptosis, cytokine production, and reprogramming of T cells.126 TEXs are able to induce apoptosis of activated CD8+ effecter T cells by activating the Fas/Fas ligand pathway and promote the expansion of Treg cells, thus contributing to immune suppression and tumor escape.127. The gene discussed is CD8A; the disease is neoplasm.