One study has showed that exosomes derived from CD8+ T cells can be endocytosed by APCs through MHC‐I/TCR interactions and this inhibit DCs mediated antigen‐specific CD8+ CTL responses (Figure 5b).162 Overall, the current research on immune cell exosomes lags far behind the direction of tumor cell exosomes. This evidence concerns the gene CD8A and neoplasm.