Both the large tumor suppressor 1 (LATS1) and LATS2 are key kinases in Hippo pathway that controls organ development and mainly play tumor‐suppressive roles by targeting YAP/TAZ for proteasomal degradation.128, 129, 130 Unexpectedly, loss of LATS1/2 inhibits tumor growth and metastasis by enhancing immunogenicity of tumor cells and anti‐tumor immune responses. This evidence concerns the gene LATS1 and neoplasm.