Generation of the fused protein CBP-MOZ is the result of the t(8,16)(p11,p13) translocation in AML.181 Translocation of t(10;16)(q22;p13) leads to the CBP-MORF chimera.182 Similarly, p300-MOZ, MLL-CBP, and MLL-p300 (MLL, mixed lineage leukemia) have also been identified in hematological malignancies.183–185 Generally, chromosomal rearrangements involving CBP are more common than those involving p300. Here, EP300 is linked to acute myeloid leukemia.