MBD2 and colonic neoplasm: MBD proteins cooperate with other proteins to regulate gene transcription.57,58 However, the role of MBD1 and MBD2 has not been identified in human lung or colon cancer, with only limited mutations being detected.59 Furthermore, loss of MBD1 did not show any carcinogenic effect in MBD−/− mice.60 Compared with MBD1, MBD2 shows more effect on tumorigenesis.