Inhibition of LSD1 leads to global H3K4 methylation and promotes differentiation of neuroblastoma cells.408 Unlike KDM1A, KDM1B is mostly involved in growing oocytes with a restricted expression pattern.409 Similar to the dual roles of LSD1, members of the KDM2 family can either promote tumor formation or inhibit tumorigenesis.410 Through dimethylating H3K36 in DUSP3 (dual specific phosphatase 3), KDM2A activates ERK1/2 expression in lung cancer cells.411 Knockout of KDM2B in breast cancer downregulates the tumor stem cell markers ALDH and CD44 via the repression of polycomb complexes. The gene discussed is DUSP3; the disease is breast cancer.