Generation of the fused protein CBP-MOZ is the result of the t(8,16)(p11,p13) translocation in AML.181 Translocation of t(10;16)(q22;p13) leads to the CBP-MORF chimera.182 Similarly, p300-MOZ, MLL-CBP, and MLL-p300 (MLL, mixed lineage leukemia) have also been identified in hematological malignancies.183–185 Generally, chromosomal rearrangements involving CBP are more common than those involving p300. The gene discussed is KAT6A; the disease is acute myeloid leukemia.