Aberrant expression of KDM4 family members might lead to instability of the genome and become involved in tumorigenesis.410 Members of the KDM6 family usually act as tumor suppressors and are thought to cause cell growth arrest.418 For example, the tumor suppressor proteins p16INK4A and p14ARF, encoded by the INK4A-ARF locus, are repressed by H3K27me3. Here, CDKN2A is linked to neoplasm.