Alteration of the EZH2-induced methylation of H3K27 has been observed in multiple cancers, including various solid tumors (prostate, breast, kidney, bladder, and lung cancers) and hematological malignancies.392 Meanwhile, overexpression of EZH2 has been found in multiple cancers and is associated with poor prognosis.393 Different mechanisms have been proposed to describe the role of EZH2 in tumorigenesis (Table 3). The gene discussed is EZH2; the disease is lung cancer.