Deficiency of MBD2 strongly suppresses intestinal tumorigenesis in APCMin-background mice.61 A possible reason is that many important signaling pathways are downregulated in colorectal cancer, and loss of MBD2 leads to reexpression of these genes.62 Meanwhile, inhibition of MBD2 shows promising effects on suppression of the tumorigenesis of human lung cancer and colon cancer.63 Although MBD3 does not directly bind to methylated DNA, it regulates the methylation process via interactions with other proteins, such as MBD2 and HDAC. This evidence concerns the gene HDAC9 and lung cancer.