BRD4 and cancer: JQ1 is a cell-permeable small molecule and can competitively bind to BRD4 fusion oncoproteins, such as BRD4-NUT, resulting in cancer cell differentiation and apoptosis.614 Similarly, I-BET762 is also a synthetic mimic of and competes with BRD4.615 Other compounds, such as MS417, OTX-015, RVX-208, OXFBD, I-BET151, PFI-1, MS436, and XD14, are also BET inhibitors and have been well illustrated in other published papers.616 We will focus on the associations between these compounds and cancers.