Signal transducers and activators of transcription (STAT) proteins make up a family of 7 different proteins (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, and STAT7) that recruit Janus kinases (JAKs) by activating different proteins.39 The JAK–STAT pathways is involved and activated in various solid tumors, including NSCLC.40 The JAK–STAT pathways plays important roles in cells differentiation, proliferation, and cancer progression. The gene discussed is SOAT1; the disease is cancer.