A PI3K inhibitor (LY294002) has been reported to enhance the sensitivity of NSCLC to chemotherapy and radiation.13 In addition, another mTOR inhibitor, temsirolimus (CCI-779), which targets molecules downstream of the PI3K pathways, has shown promising antitumor activity in phase I trials of NSCLC.14 Other PI3K/AKT/mTOR inhibitors, everolimus (RAD001 or AP23573), is also in preclinical trails. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.