These data further support the significance of ongoing clinical trials testing patritumab combined with EGFR-TKIs, such as erlotinib, to treat NSCLC patients with high expression of HRG.54 However, studies found that the antitumor activity of patritumab could be limited by combination treatment with erlotinib in patients with EGFR-TKI resistance acquired after therapy. Here, EGFR is linked to non-small cell lung carcinoma.