A phase I clinical trial combining patritumab with erlotinib showed an overall response rate of 4.2% and a disease control rate of 62.5% in Japanese patients with advanced NSCLC.68 Similarly, a phase III study of patritumab combined with erlotinib in EGFR wild-type patients with locally advanced or metastatic NSCLC that had progressed on at least one prior systemic therapy was terminated.69 Thus, an alternative HER3-targeting therapy is required for EGFR-mutant NSCLC treatment. The gene discussed is ERBB3; the disease is non-small cell lung carcinoma.