CASP3 and neoplasm: The authors demonstrated that a JAK2 inhibitor (ruxolitinib) blunted the growth of cisplatin-resistant H1299 cells and enhanced antitumor activity by inhibiting tumor growth and inducing caspase-3 expression in tumor models with cisplatin resistance.44 However, further study of the efficacy and safety of combination treatments with JAK2 inhibitors is needed.