In addition, a limited dilution xenograft assay revealed that 105 of TGIF2-silenced H1299 cells xenografted in NOD/SCID mice showed a dramatically decreased incidence of initiating a tumor when compared with that of control cells (Fig. 3f), which could also be restored by increasing TGIF2 levels (Fig. 3f). Here, TGIF2 is linked to neoplasm.