PINT87aa directly binds to polymerase-associated factor complex (PAF1c) and inhibits several oncogenes downstream of PAF1c, including CEBP1, cyclin D1, C-myc, Sox2, etc. In biological function, PINT87aa overexpression can suppress glioblastoma in vitro and in vivo.106 An ideal targeted therapeutic drug should effectively kill or inhibit tumor cells while not damaging normal tissue cells. The gene discussed is LINC-PINT; the disease is glioblastoma.