We identified four cervical cancer-specific methylation markers, including cg07211381 (RAB3C), cg12205729 (GABRA2), cg20708961 (ZNF257), and cg26490054 (SLC5A8), and the significantly decreased expression of GABRA2, ZNF257, and SLC5A8 in CSCC was further confirmed in human CSCC tissues by IHC. This evidence concerns the gene ZNF257 and cervical cancer.