The small GTPases Rab5 and EEA1 play a rate-limiting role in membrane docking or fusion in the early endocytic pathway [17, 18], and our previous study suggested that KCa3.1 is transported into early endosomes via a Rab5c- and EEA1-dependent process in Fabry disease [12]. Here, RAB5C is linked to Fabry disease.