TRPC3 and Hypertension: Here, we undertook this study to test the following hypotheses: (1) the expression level of TRPC3 from atrial fibroblast is upregulated in aging and hypertension, which is involved in atrial fibrosis; (2) TRPC3 was upregulated through TGF-β1/Smad signaling pathways to promote atrial remodeling.