Herein, we show that the SH-SY5Y neuroblastoma cell line expresses NOX2 components, FPR1, and TrkA, and that FPR1 stimulation by formylated peptides induces NADPH-dependent ROS generation, as well as the phosphorylation of Y490, Y751, and Y785 residues of TrkA. This evidence concerns the gene CYBB and neuroblastoma.