MAPT and early-onset autosomal dominant Alzheimer disease: Based on these in vitro findings, we next verified whether the neuroprotective effects of Artemether found in neuronal cultures can be measured in the triple transgenic mouse model of Alzheimer's disease (3xTg-AD), which exhibits the increase of amyloid-β oligomer accumulation in an age-dependent manner and extracellular plaques and tau pathology in the brain paralleled by learning and memory impairment [37].