In turn, HO-1, SOD proteins decreased levels of ROS and anti-inflammatory mediators, decreased the inflammation process, decreased deposition of amyloid-β and tau hyperphosphorylation, significantly attenuated aponecrosis and other cell death processes, and finally conferred neuroprotection in vitro and in vivo in Alzheimer's disease models (Figure 12). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.