HMOX1 and early-onset autosomal dominant Alzheimer disease: In turn, HO-1, SOD proteins decreased levels of ROS and anti-inflammatory mediators, decreased the inflammation process, decreased deposition of amyloid-β and tau hyperphosphorylation, significantly attenuated aponecrosis and other cell death processes, and finally conferred neuroprotection in vitro and in vivo in Alzheimer's disease models (Figure 12).