More importantly, pterostilbene and allopurinol with antioxidant capacity downregulated Pitx2c to increase miR-15b expression and suppressed p-p53 to reduce TGF-β1/Smads signaling activation and CTGF expression, resulting in the attenuation of fructose-induced myocardial fibrosis. Here, TP53 is linked to Myocardial fibrosis.