Pterostilbene and allopurinol with antioxidant activity downregulate Pitx2c and upregulate miR-15b and then suppress p-p53-dependent TGF-β1/Smads signaling activation to reduce CTGF, resulting in the alleviation of fructose-induced myocardial fibrosis. Here, TP53 is linked to Myocardial fibrosis.