It also reduces oxidative stress and p53 overexpression in oxidized low-density lipoprotein-induced human umbilical vein endothelial cell apoptosis [27], inhibits TGF-β1/Smads signaling and α-SMA expression, and alleviates dimethylnitrosamine-induced liver fibrosis in rats [28]. Here, TGFB1 is linked to Hepatic fibrosis.