TP53 and Myocardial fibrosis: In this study, we firstly reported that pterostilbene and allopurinol with antioxidant capacity potentially downregulated Pitx2c to increase miR-15b expression and hence reduced p-p53-dependent TGF-β1/Smads signaling activation, being consistent with the alleviation of fructose-induced myocardial fibrosis.