So, in this study, we investigated the inhibition effects on expression levels of IL-1β, caspase-1, NLRP3, and NQO1 in hydrogen peroxide (H2O2)-induced RAW264.7 macrophages and expression and secretion of IL-1β, IL-6, and TNF-α from MSU crystal-induced THP-1 cells to investigate the mechanism of HZTF in treating gouty arthritis. This evidence concerns the gene NLRP3 and gout.