With the progression of gastric mucosal lesions, the expression level of OSM in chronic gastritis, LGIN, HGIN, and EGC gradually increased, and there was a significant difference in the expression level of mRNA among EGC, HGIN, which has higher malignant potential, and LGIN, which is relatively benign, as shown in Figure 1. The gene discussed is OSM; the disease is chronic gastritis.