Cytokines and key transcription factors activating precancerous cells, IL-6 family members, and related signaling pathways may participate in the formation of positive feedback loops during tumorigenesis and development (NF-kappa B and STAT3 are important signaling pathways of tumor immunity) [27], for example, NF-kappa B can promote the production of IL-6 family cytokines, while the IL-6 family can activate downstream STAT3 signaling pathways. This evidence concerns the gene STAT3 and neoplasm.