There are currently more reliable assumptions about this phenomenon: (1) Helicobacter pylori infection, accompanied by atrophy of gastric body and loss of parietal cells, resulting in reduced reflux, which reduces the incidence of reflux esophagitis and Barrett's esophagus [66]; (2) Helicobacter pylori infection can induce apoptosis of esophageal adenocarcinoma cells progressing from Barrett's esophagus through Fas apoptotic pathway mediated by Caspase [60]. The gene discussed is FAS; the disease is esophageal adenocarcinoma.