As one of the key effectors in the innate immune system, type I interferon (IFN) plays diverse roles in host defense against virus infection and has been recommended or studied as important/potential therapy in patients with virus infections such as hepatitis B virus (HBV) [1], hepatitis C virus (HCV) [2], hepatitis D virus (HDV) [3], and enterovirus 71 [4]. Here, IFNA1 is linked to viral infectious disease.