Another investigation of familial LVNC patients underlined the contribution of NKX2-5 variant as a genetic modifier of LVNC in conjunction of missense mutations in MYH7 and MKL2 genes, confirmed by genome-edited mouse models and patient-derived iPSC-CMs (Gifford et al., 2019). The gene discussed is NKX2-5; the disease is left ventricular noncompaction.