MAPT and Cognitive impairment: These patients presented with FTD with behavioral symptoms and cognitive deficits including semantic impairment; previous reports of the phenotype of MAPT mutations are consistent with this, for example, in a large series from Manchester, many patients had associated semantic impairment (evidenced by anomia, semantic naming errors, and impaired word and/or object comprehension) in conjunction with behavioral change (Snowden et al., 2015).