In Australia, government-subsidized treatment with an ERA or a PDE-5-inhibitor is only available for SSc-PAH patients, which would explain the low use of these medications in our cohort and sole use in those with concurrent PAH (with 20.8% of DU patients having been treated with a PDE-5-inhibitor and 27.9% an ERA). The gene discussed is PDE5A; the disease is systemic sclerosis.