MiR-485-5p has been widely reported as a tumor inhibitor in multiple cancers, such as colorectal cancer [23], osteosarcoma [15], breast cancer [24] et al. In glioma, miR-485-5p was dramatically down-regulated and suppressed cell proliferation, and promoted glioma cells cycle arrest in G1 by binding to paired box 3 (PAX3) [25]. Here, PAX3 is linked to central nervous system cancer.