A possible functional role for somatic SNCA CNVs in the SN is suggested at the single-cell level by their apparent association with the presence of α-synuclein inclusions in the same cell, in a cell-type specific manner: in NM- cells in MSA-SND (RR 4.16), and in NM+ cells in LB cases (RR 6.03). The gene discussed is SNCA; the disease is multiple system atrophy.