Indeed, compared with CD4+ and CD8+ T cells purified from the same bone marrow aspirates, CD34+ HSCs exhibited significantly elevated expression of 5-AZA ISGs and of 5-AZA-responsive ERVs in healthy donors and in untreated MDS, CMML and AML patients in our cohort (Additional file 2: Figure S6). This evidence concerns the gene CD8A and acute myeloid leukemia.