PlGF-2123-144-α-TNF even at 0.1 μg completely suppressed the arthritis score at the treated paw (Fig. 6a), and joint histology in the treated paw appeared normal, whereas synovial proliferation, leukocyte infiltration, and cartilage degeneration were observed in untreated control joint (Fig. 6b). The gene discussed is PGF; the disease is arthritic joint disease.