On one hand, consistent with the known knowledge that cytoplasmic lncRNAs as a ceRNA in modulating cancer development by affecting protein-coding genes at post-transcriptional level via secluding miRNAs [37, 38], we firstly revealed that cytoplasmic HOXC-AS1 acted as a ceRNA of MYC mRNA in GC cells through competitively interacting with miR-590-3p. The gene discussed is MYC; the disease is cancer.