In another study conducted in Iran involving 260 women with PCOS and 221 controls, the distribution of genotypes and alleles of VDR gene variants did not differ between women with PCOS and controls; however, the “A” allele of the rs757343 VDR gene polymorphism was associated with an increased risk of severe PCOS phenotype development [13]. Here, VDR is linked to polycystic ovary syndrome.