Behaviours indicative of sickness include lethargy, depression, anxiety, anorexia, social withdrawal and isolation, and have consistently been associated with augmented levels of pro-inflammatory cytokines, especially tumour necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1 beta (IL-1ß) [21]. The gene discussed is IL1B; the disease is major depressive disorder.